Take the A1 motorway, exit at Valdichiana-Bettolle, cross the village of Bettolle and follow the signs for Torrita di Siena.Arrived at Torrita di Siena, at the traffic light, turn left towards Montepulciano.
Take the A1 motorway, exit at Chiusi-Chianciano Terme, follow the signs for Chianciano Terme.Cross the village of Chianciano Terme and continue towards Montepulciano.
Chiusi-Chianciano Terme railway station (20 km) on the main line Rome-Florence-Bologna-Milan.
Continue with the regional train to Siena and get off at Montepulciano station: Empoli-Siena-Chiusi line.
The closest airports to Montepulciano are:
Florence: Firenze-Peretola, “Amerigo Vespucci” airport, about 126 km from Montepulciano, the time to drive by car is about 1 and a half hours.
Pisa: Airport “Galileo Galilei”, about 217 km from Montepulciano, the journey time by car is about 2 hours.
Rome: Leonardo da Vinci Airport, about 200 Km from Montepulciano, it takes about 2 hours to travel by car.